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Oncoimmunology. 2012 Jul 1;1(4):539-540.

Engineering hematopoietic stem cells to create melanoma specific CTL.

Author information

  • Department of Medicine; Division of Hematology-Oncology; UCLA AIDS Institute; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA; David Geffen School of Medicine at UCLA; Los Angeles, CA USA.

Abstract

Using a humanized mouse model, we developed melanoma specific CD8 T cells from genetically modified human hematopoietic stem cells (hHSC). The transgenic T cells were functional both in vivo and ex vivo, effectively limiting and clearing tumor growth. Finally, the transduced hHSC stably populated the bone marrow.

PMID:
22754779
[PubMed]
PMCID:
PMC3382894
Free PMC Article

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