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Int J Mol Sci. 2012;13(5):6440-51. doi: 10.3390/ijms13056440. Epub 2012 May 24.

Phytochemical and Biological Studies of Agave attenuata.

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  • 1Department of Chemistry, Government College University, Faisalabad 38000, Pakistan; E-Mails: (K.R.); (M.Z.); (N.R.); (M.R.).


The present study was conducted to examine various biological activities of a methanol extract of Agave attenuata leaves. GC-MS analysis of the n-hexane fraction from the extract revealed the presence of 31 compounds, with mono-2-ethylhexyl phthalate (11.37%), 1,2-benzenedicarboxylic acid (6.33%), n-docosane (6.30%) and eicosane (6.02%) as the major components. The leaves contained appreciable levels of total phenolic contents (10.541-39.35 GAE, mg/100 g) and total flavonoid contents (43.35-304.8 CE, mg/100 g). The extract and some of its fractions showed moderate antimicrobial effects. Leaves extract and fractions also exhibited a good antioxidant potential when measured by DPPH radical scavenging activity and inhibition of lipid peroxidation assays. The hemolytic effect of the plant was found to be in a range of 1.01%-2.64%. From the present study it is concluded that this plant could be used as a source of natural antioxidants and functional food nutraceutical applications.


Agave attenuata; GC-MS; flavonoids; peroxidation; phenolics; volatile fraction

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