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Clin Infect Dis. 2012 Aug;55 Suppl 2:S88-92. doi: 10.1093/cid/cis335.

Burden of Clostridium difficile on the healthcare system.

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  • 1Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA.


There are few high-quality studies of the costs of Clostridium difficile infection (CDI), and the majority of studies focus on the costs of CDI in acute-care facilities. Analysis of the best available data, from 2008, indicates that CDI may have resulted in $4.8 billion in excess costs in US acute-care facilities. Other areas of CDI-attributable excess costs that need to be investigated are costs of increased discharges to long-term care facilities, of CDI with onset in long-term care facilities, of recurrent CDI, and of additional adverse events caused by CDI.

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