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J Clin Invest. 2012 Jul 2;122(7):2337-43. doi: 10.1172/JCI60434. Epub 2012 Jul 2.

Hooked! Modeling human disease in zebrafish.

Author information

  • 1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.

Abstract

Zebrafish have been widely used as a model system for studying developmental processes, but in the last decade, they have also emerged as a valuable system for modeling human disease. The development and function of zebrafish organs are strikingly similar to those of humans, and the ease of creating mutant or transgenic fish has facilitated the generation of disease models. Here, we highlight the use of zebrafish for defining disease pathways and for discovering new therapies.

PMID:
22751109
[PubMed - indexed for MEDLINE]
PMCID:
PMC3386812
Free PMC Article
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