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Immunity. 2012 Jun 29;36(6):901-3. doi: 10.1016/j.immuni.2012.06.001.

Bystanders not so innocent after all.

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  • 1Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia.

Abstract

Interleukin 27 (IL-27) regulates immune responses, including T helper 17 (Th17) cell activity. In this issue of Immunity, Hirahara et al. (2012) demonstrate that IL-27 suppresses Th17 cells in trans through induction of the inhibitory ligand PD-L1 on bystander T cells.

Copyright © 2012 Elsevier Inc. All rights reserved.

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PMID:
22749349
[PubMed]
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