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Immunity. 2012 Jun 29;36(6):895-6. doi: 10.1016/j.immuni.2012.06.008.

Dampening NF-κB signaling by "self-eating".

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  • 1Department of Molecular and Cellular Oncology, University of Texas, M.D. Anderson Cancer Center, Houston, TX 77030, USA.


Activation of NF-κB transcription factor is crucial for survival, proliferation, and differentiation of T cells. In this issue of Immunity, Paul et al. (2012) demonstrate that autophagy is a pathway by which TCR-activated NF-κB is turned over.

Copyright © 2012 Elsevier Inc. All rights reserved.

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