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Curr Opin Struct Biol. 2012 Aug;22(4):413-20. doi: 10.1016/j.sbi.2012.06.001. Epub 2012 Jun 27.

Structural insights for engineering binding proteins based on non-antibody scaffolds.

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  • 1Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA. skoide@uchicago.edu

Abstract

Engineered binding proteins derived from non-antibody scaffolds constitute an increasingly prominent class of reagents in both research and therapeutic applications. The growing number of crystal structures of these 'alternative' scaffold-based binding proteins in complex with their targets illustrate the mechanisms of molecular recognition that are common among these systems and those unique to each. This information is useful for critically assessing and improving/expanding engineering strategies. Furthermore, the structural features of these synthetic proteins produced under tightly controlled, directed evolution deepen our understanding of the underlying principles governing molecular recognition.

Copyright © 2012 Elsevier Ltd. All rights reserved.

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