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Sci China Life Sci. 2012 Jun;55(6):533-41. doi: 10.1007/s11427-012-4316-9. Epub 2012 Jun 29.

Protein photo-folding and quantum folding theory.

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  • 1Faculty of Physical Science and Technology, Inner Mongolia University, Hohhot 010021, China. lolfcm@mail.imu.edu.cn

Abstract

The rates of protein folding with photon absorption or emission and the cross section of photon -protein inelastic scattering are calculated from quantum folding theory by use of a field-theoretical method. All protein photo-folding processes are compared with common protein folding without the interaction of photons (non-radiative folding). It is demonstrated that there exists a common factor (thermo-averaged overlap integral of the vibration wave function, TAOI) for protein folding and protein photo-folding. Based on this finding it is predicted that (i) the stimulated photo-folding rates and the photon-protein resonance Raman scattering sections show the same temperature dependence as protein folding; (ii) the spectral line of the electronic transition is broadened to a band that includes an abundant vibration spectrum without and with conformational transitions, and the width of each vibration spectral line is largely reduced. The particular form of the folding rate-temperature relation and the abundant spectral structure imply the existence of quantum tunneling between protein conformations in folding and photo-folding that demonstrates the quantum nature of the motion of the conformational-electronic system.

PMID:
22744184
[PubMed - indexed for MEDLINE]
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