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Case Rep Ophthalmol. 2012 May;3(2):196-9. doi: 10.1159/000339656. Epub 2012 Jun 12.

Intravitreal bevacizumab for photodynamic therapy-induced massive macular detachment in acute central serous chorioretinopathy.

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  • 1Department of Ophthalmology, University of Thessaly School of Medicine, Larissa, Greece.


We present a long followed up case of acute central serous chorioretinopathy (CSC) complicated by a severe visual loss due to massive pigment epithelium detachment of the macula after a full-dose photodynamic therapy (PDT). Rapid anatomical and functional improvement was observed after a single intravitreal injection of bevacizumab. To our knowledge, we report the first case of PDT-treated CSC complicated by severe visual loss. We can only speculate that the serous detachment of the posterior pole might have been caused by PDT-induced VEGF overexpression, explaining such an impressive response to Avastin treatment.


Bevacizumab; Central serous chorioretinopathy; Photodynamic therapy

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