Format

Send to

Choose Destination
See comment in PubMed Commons below
Am J Med Sci. 2012 Sep;344(3):237-40. doi: 10.1097/MAJ.0b013e318256041f.

Numb chin syndrome in acute myeloid leukemia.

Author information

  • 1Medical Scientist Training Program and Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29403, USA.

Abstract

Numb chin syndrome (NCS) is a rare cranial neuropathy characterized by facial numbness in the distribution of the mental branch of the inferior alveolar nerve. Although commonly associated with local trauma, NCS can indicate an underlying neoplastic condition. Although NCS is most commonly associated with nonmalignant disease states, it may be the presenting symptom of a systemic malignancy, and its prompt recognition is essential for proper management. NCS is associated with a variety of neoplastic conditions but is most commonly seen with lymphoproliferative conditions, breast cancer and prostate cancer. When confronted with a possible diagnosis of NCS, clinical evaluation should include evaluation for occult malignancy or relapse of any known previous cancer. In this study, a case of a patient with NCS in the context of a new diagnosis of acute myeloid leukemia with differentiation with a t(8;21) translocation is presented and the literature regarding the multiple etiologies and significance of NCS reviewed.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk