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J Clin Gastroenterol. 2013 Feb;47(2):136-8. doi: 10.1097/MCG.0b013e3182582cbf.

Cyclic vomiting associated with excessive dopamine in Riley-day syndrome.

Author information

  • 1Department of Physiology and Neuroscience, New York University School of Medicine, New York, NY, USA. Horacio.Kaufmann@nyumc.org

Abstract

GOALS:

To analyze the neurochemical profile during the recurrent attacks of nausea and vomiting in patients with Riley-day syndrome.

BACKGROUND:

One of the most disabling features of patients with Riley-day syndrome are recurrent attacks of severe nausea/retching/vomiting accompanied by hypertension, tachycardia, and skin flushing, usually triggered by emotional or other stresses.

STUDY:

We monitored blood pressure and heart rate and measured plasma catecholamines during typical dysautonomic crises triggered by emotionally charged situations. For comparison, measurements were repeated at follow-up after the symptoms had resolved and the patients were feeling calm and well.

RESULTS:

During a typical attack, patients were hypertensive and tachycardic. In all patients, circulating levels of norepinephrine (P < 0.002) and dopamine (P < 0.007) increased significantly.

CONCLUSIONS:

Activation of dopamine receptors in the chemoreceptor trigger zone may explain the cyclic nausea/retching/vomiting of patients with Riley-day syndrome.

PMID:
22739220
[PubMed - indexed for MEDLINE]
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