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    Biochem J. 2012 Aug 15;446(1):159-63. doi: 10.1042/BJ20120658.

    A novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps.

    Source

    Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.

    Abstract

    MCs (mast cells) are critical components of the host innate immune defence against bacterial pathogens, providing a variety of intra- and extra-cellular antimicrobial functions. In the present study we show, for the first time, that the transcriptional regulator HIF-1α (hypoxia-inducible factor-1α) mediates the extracellular antimicrobial activity of human and murine MCs by increasing the formation of MCETs (MC extracellular traps).

    PMID:
    22738198
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC3606900
    [Available on 2013/8/15]

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