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Biochem J. 2012 Aug 15;446(1):159-63. doi: 10.1042/BJ20120658.

A novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps.

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  • 1Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.


MCs (mast cells) are critical components of the host innate immune defence against bacterial pathogens, providing a variety of intra- and extra-cellular antimicrobial functions. In the present study we show, for the first time, that the transcriptional regulator HIF-1α (hypoxia-inducible factor-1α) mediates the extracellular antimicrobial activity of human and murine MCs by increasing the formation of MCETs (MC extracellular traps).

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