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Oncoimmunology. 2012 May 1;1(3):390-392.

Smoothing T cell roads to the tumor: Chemokine post-translational regulation.

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  • 1Istituto Oncologico Veneto IRCCS; Padua, Italy.

Abstract

We described a novel tumor-associated immunosuppressive mechanism based on post-translational modifications of chemokines by reactive nitrogen species (RNS). To overcome tumor immunosuppressive hindrances, we designed and developed a new drug, AT38, that inhibits RNS generation at the tumor site. Combinatorial approaches with AT38 boost the effectiveness of cancer immunotherapy protocols.

PMID:
22737626
[PubMed]
PMCID:
PMC3382857
Free PMC Article

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