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Br J Cancer. 2012 Jul 10;107(2):255-9. doi: 10.1038/bjc.2012.277. Epub 2012 Jun 26.

The impact of population-based faecal occult blood test screening on colorectal cancer mortality: a matched cohort study.

Author information

  • 1Scottish Bowel Screening Research Unit, Kings Cross, Clepington Road, Dundee DD3 8EA, UK. g.libby@dundee.ac.uk

Abstract

BACKGROUND:

Randomised trials show reduced colorectal cancer (CRC) mortality with faecal occult blood testing (FOBT). This outcome is now examined in a routine, population-based, screening programme.

METHODS:

Three biennial rounds of the UK CRC screening pilot were completed in Scotland (2000-2007) before the roll out of a national programme. All residents (50-69 years) in the three pilot Health Boards were invited for screening. They received a FOBT test by post to complete at home and return for analysis. Positive tests were followed up with colonoscopy. Controls, selected from non-pilot Health Boards, were matched by age, gender, and deprivation and assigned the invitation date of matched invitee. Follow-up was from invitation date to 31 December 2009 or date of death if earlier.

RESULTS:

There were 379 655 people in each group (median age 55.6 years, 51.6% male). Participation was 60.6%. There were 961 (0.25%) CRC deaths in invitees, 1056 (0.28%) in controls, rate ratio (RR) 0.90 (95% confidence interval (CI) 0.83-0.99) overall and 0.73 (95% CI 0.65-0.82) for participants. Non-participants had increased CRC mortality compared with controls, RR 1.21 (95% CI 1.06-1.38).

CONCLUSION:

There was a 10% relative reduction in CRC mortality in a routine screening programme, rising to 27% in participants.

PMID:
22735907
[PubMed - indexed for MEDLINE]
PMCID:
PMC3394992
Free PMC Article

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