Format

Send to

Choose Destination
See comment in PubMed Commons below
Chromosome Res. 2012 Jul;20(5):547-61. doi: 10.1007/s10577-012-9289-9.

Establishment of the vertebrate kinetochores.

Author information

  • 1Department of Molecular Genetics, National Institute of Genetics and Graduate University for Advanced Studies, Mishima, Shizuoka 411-8540, Japan. thori@lab.nig.ac.jp

Abstract

The centromere is essential for accurate chromosome segregation during mitosis and meiosis to achieve transmission of genetic information to daughter cells. To facilitate accurate chromosome segregation, the centromere serves several specific functions, including microtubule binding, spindle-checkpoint control, and sister chromatid cohesion. The kinetochore is formed on the centromere to achieve these functions. To understand kinetochore structure and function, it is critical to identify the protein components of the kinetochore and characterize the functional properties of each component. Here, we review recent progress with regard to the molecular architecture of the kinetochore and discuss the future directions for centromere biology.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Write to the Help Desk