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Chem Res Toxicol. 2012 Sep 17;25(9):1793-9. doi: 10.1021/tx300164j. Epub 2012 Jun 25.

Boronate probes as diagnostic tools for real time monitoring of peroxynitrite and hydroperoxides.

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  • 1Department of Biophysics, Free Radical Research Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Abstract

Boronates, a group of organic compounds, are emerging as one of the most effective probes for detecting and quantifying peroxynitrite, hypochlorous acid, and hydrogen peroxide. Boronates react with peroxynitrite nearly a million times faster than with hydrogen peroxide. Boronate-containing fluorogenic compounds have been used to monitor real time generation of peroxynitrite in cells and for imaging hydrogen peroxide in living animals. This perspective highlights potential applications of boronates and other fluorescent probes to high-throughput analyses of peroxynitrite and hydroperoxides in toxicological studies.

PMID:
22731669
[PubMed - indexed for MEDLINE]
PMCID:
PMC3501381
Free PMC Article
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