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Gen Hosp Psychiatry. 2013 Jul-Aug;35(4):452.e1-3. doi: 10.1016/j.genhosppsych.2012.05.012. Epub 2012 Jun 21.

Olanzapine treatment of premenstrual onset psychosis: a case report.

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  • 1Department of Psychiatry, Taipei Veterans General Hospital Su-Ao Branch, Taiwan.



Premenstrual onset psychosis is a rare condition of unknown etiology for which no treatment trials have been conducted and whose existence as a definitive diagnosis continues to be debated. The literature includes individual case reports and small case series, leaving psychiatrists to make decisions about prescribing antipsychotic agents on a case-by-case basis. Moreover, researchers continue to debate the efficacy of antipsychotic agents in the treatment of premenstrual onset psychosis.


Case report.


We report the case of a 17-year-old female with recurrent premenstrual onset psychosis that was successfully treated with olanzapine monotherapy (20 mg/day).


These findings may serve as a reminder to physicians to rethink the suitability of a more traditionally accepted diagnosis, including premenstrual exacerbation of bipolar disorder or schizophrenia, and the potentially important role of antipsychotic agents, especially prolactin-sparing ones, in premenstrual onset psychosis.

Copyright © 2013 Elsevier Inc. All rights reserved.

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