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Leuk Res. 2012 Oct;36(10):1255-61. doi: 10.1016/j.leukres.2012.05.016. Epub 2012 Jun 21.

A clinical trial of supervised exercise for adult inpatients with acute myeloid leukemia (AML) undergoing induction chemotherapy.

Author information

  • 1Department of Medicine, University Health Network, Toronto, ON, Canada. shabbir.alibhai@uhn.on.ca

Abstract

Patients with acute myeloid leukemia (AML) receiving induction chemotherapy (IC) were enrolled in a supervised exercise intervention to determine safety, feasibility, and efficacy. Physical fitness measures, quality of life (QOL) and fatigue were assessed using standardized measures at baseline, post-induction, and post first consolidation. Retention was excellent, the intervention was safe, and efficacy estimates suggested benefits in physical fitness and QOL outcomes. Exercise is a safe, promising intervention for improving fitness and QOL in this patient population. These results provide a foundation for a randomized trial to better understand the impact of exercise during IC on clinically important outcomes.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT01170598.

Copyright © 2012 Elsevier Ltd. All rights reserved.

PMID:
22726923
[PubMed - indexed for MEDLINE]
PMCID:
PMC3767429
Free PMC Article
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