Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Immunol. 2012 Oct;33(10):522-30. doi: 10.1016/j.it.2012.05.008. Epub 2012 Jun 20.

Cell-intrinsic innate immune control of West Nile virus infection.

Author information

  • 1Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA. diamond@borcim.wustl.edu

Abstract

West Nile virus (WNV) is an enveloped positive-stranded RNA virus that has emerged over the past decade in North America to cause epidemics of meningitis, encephalitis, and acute flaccid paralysis in humans. WNV has broad species specificity, and replicates efficiently in many cell types, including those of the innate immune and central nervous systems. Recent studies have defined the pathogen recognition receptor (PRR) and signaling pathways by which WNV is detected, and several effector mechanisms that contribute to protective cell-intrinsic immunity. This review focuses on recent advances in identifying the host sensors that detect WNV, the adaptor molecules and signaling pathways that regulate the induction of interferon (IFN)-dependent defenses, and the proteins that limit WNV replication, spread, and disease pathogenesis.

Copyright © 2012 Elsevier Ltd. All rights reserved.

PMID:
22726607
[PubMed - indexed for MEDLINE]
PMCID:
PMC3461102
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk