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Cell. 2012 Jun 22;149(7):1622-34. doi: 10.1016/j.cell.2012.04.041.

Expressed pseudogenes in the transcriptional landscape of human cancers.

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  • 1Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA.

Abstract

Pseudogene transcripts can provide a novel tier of gene regulation through generation of endogenous siRNAs or miRNA-binding sites. Characterization of pseudogene expression, however, has remained confined to anecdotal observations due to analytical challenges posed by the extremely close sequence similarity with their counterpart coding genes. Here, we describe a systematic analysis of pseudogene "transcription" from an RNA-Seq resource of 293 samples, representing 13 cancer and normal tissue types, and observe a surprisingly prevalent, genome-wide expression of pseudogenes that could be categorized as ubiquitously expressed or lineage and/or cancer specific. Further, we explore disease subtype specificity and functions of selected expressed pseudogenes. Taken together, we provide evidence that transcribed pseudogenes are a significant contributor to the transcriptional landscape of cells and are positioned to play significant roles in cellular differentiation and cancer progression, especially in light of the recently described ceRNA networks. Our work provides a transcriptome resource that enables high-throughput analyses of pseudogene expression.

Copyright © 2012 Elsevier Inc. All rights reserved.

Comment in

  • The great pretenders. [Nat Rev Cancer. 2012]
PMID:
22726445
[PubMed - indexed for MEDLINE]
PMCID:
PMC3597446
Free PMC Article

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