Leg Med (Tokyo). 2012 Nov;14(6):320-3. doi: 10.1016/j.legalmed.2012.05.002. Epub 2012 Jun 20.

A case of Amelogenin Y-null: a simple primer binding site mutation or unusual genetic anomaly?

Davis C, Illescas M, Tirado C, Lopez R, Budowle B, Cruz TD.

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Institute of Applied Genetics, Department of Forensic and Investigative Genetics, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107, United States. Carey.davis@unthsc.edu

Abstract

A thirteen year old boy was murdered by a gunshot wound to the head. In order to confirm identity of the boy, samples were sent to the Instituto de Ciencias Forenses de Puerto Rico (PR-ICF) DNA laboratory. Autosomal DNA results exhibited only an X at the Amelogenin locus, whereas the autopsy results reported the child to be anatomically male. The sample was amplified with four separate YSTR marker systems. While a full Y-STR profile for the father of the boy was obtained, the boy only amplified at STR markers on the p arm of the Y chromosome. Theories that could account for this large absence of Y-STR results include an X-Y translocation or Yp isochromosome.

PMID:: 22721879; [PubMed - indexed for MEDLINE]

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Amelogenin

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A case of Amelogenin Y-null: a simple primer binding site mutation or unusual ge...
A case of Amelogenin Y-null: a simple primer binding site mutation or unusual genetic anomaly?
Leg Med (Tokyo). 2012 Nov ;14(6):320-3. doi: 10.1016/j.legalmed.2012.05.002. Epub 2012 Jun 20 .

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