Format

Send to

Choose Destination
See comment in PubMed Commons below
Int J Stroke. 2012 Jul;7(5):378-85. doi: 10.1111/j.1747-4949.2012.00839.x.

Pathophysiologic cascades in ischemic stroke.

Author information

  • 1Department of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Abstract

Many advances have been achieved in terms of understanding the molecular and cellular mechanisms of ischemic stroke. But thus far, clinically effective neuroprotectants remain elusive. In this minireview, we summarize the basics of ischemic cascades after stroke, covering neuronal death mechanisms, white matter pathophysiology, and inflammation with an emphasis on microglia. Translating promising mechanistic knowledge into clinically meaningful stroke drugs is very challenging. An integrative approach that encompasses the multimodal and multicell signaling phenomenon of stroke will be required to move forward.

© 2012 The Authors. International Journal of Stroke © 2012 World Stroke Organization.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk