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Cell Res. 2012 Nov;22(11):1518-20. doi: 10.1038/cr.2012.96. Epub 2012 Jun 19.

Indigestible mitochondria cause heartburn.

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  • 1Donald P. Shiley BioScience Center, San Diego State University, San Diego, CA 92182, USA. robbieg@sciences.sdsu.edu


The link between impaired autophagic flux (autophagus interruptus), damaged mitochondria, and myocardial inflammation has been further tightened with the recent paper by Oka and colleagues, in which failure to degrade mitochondrial DNA exacerbated myocardial inflammation in the context of pressure overload. Using mice with cardiac-specific deletion of the lysosomal DNase II that were subjected to aortic banding, Otsu's group showed that mitochondrial DNA accumulated in lysosomes and resulted in TLR9-dependent production of inflammatory cytokines.

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