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Nat Chem Biol. 2012 Aug;8(8):695-7. doi: 10.1038/nchembio.1001. Epub 2012 Jun 17.

Lys34 of translation elongation factor EF-P is hydroxylated by YfcM.

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  • 1Institute of Technology, University of Tartu, Tartu, Estonia.


Lys34 of the conserved translation elongation factor P (EF-P) is post-translationally lysinylated by YjeK and YjeA--a modification that is critical for bacterial virulence. Here we show that the currently accepted Escherichia coli EF-P modification pathway is incomplete and lacks a final hydroxylation step mediated by YfcM, an enzyme distinct from deoxyhypusine hydroxylase that catalyzes the final maturation step of eukaryotic initiation factor 5A, the eukaryotic EF-P homolog.

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