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Int J Hypertens. 2012;2012:257501. doi: 10.1155/2012/257501. Epub 2012 Jun 3.

Evaluation of clinical variables associated with increased carotid intima-media thickness in middle-aged hypertensive women.

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  • 1Department of Clinical Medicine, State University of Rio de Janeiro, Rua Vinte e Oito de Setembro, 77, Sala 329-Vila Isabel, 20551-030-Rio de Janeiro, RJ, Brazil.

Abstract

It has been previously documented that carotid intima-media thickness (cIMT) is a predictor of cardiovascular disease. The aim of this study was to identify clinical parameters associated with an increased cIMT treated hypertensive women. Female patients (n = 116) with essential hypertension, aged 40-65 years, were included in this study. Vascular ultrasound was performed and the patients were divided into two groups according to the values of cIMT (< or ≥0.9 mm). Patients with greater cIMT presented significantly higher systolic blood pressure and pulse pressure. Serum HDL-cholesterol was significantly lower and CRP was significantly higher in the same group. There was a significant correlation between cIMT and age (r = 0.25, P = 0.007), systolic blood pressure (r = 0.19, P = 0.009), pulse pressure (r = 0.30, P = 0.001), and LDL-cholesterol (r = 0.19, P = 0.043). cIMT was correlated to CRP (r = 0.31, P = 0.007) and negatively correlated to HDL-cholesterol (r = 0.33, P = 0.001). In logistic regression, only HDL-cholesterol, CRP, and pulse pressure were shown to be independent variables associated to increased cIMT. In conclusion, pulse pressure, HDL-cholesterol, and CRP are variables correlated with cIMT in treated hypertensive women.

PMID:
22701780
[PubMed]
PMCID:
PMC3371681
Free PMC Article
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