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Korean Circ J. 2012 May;42(5):345-8. doi: 10.4070/kcj.2012.42.5.345. Epub 2012 May 24.

Recurrent Deep Vein Thrombosis due to Thrombophilia.

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  • 1Department of Cardiology, Sir Salimullah Medical College & Mitford Hospital, Dhaka, Bangladesh.


Deep vein thrombosis (DVT) is a common condition that is often under-diagnosed. Acquired or hereditary defects of coagulation or a combination of these defects may facilitate the development of DVT. Recurrent DVT, a positive family history or unusual presentation may warrant investigation for hereditary thrombophilia. Investigations are best when conducted at least one month after completion of a course of anticoagulant therapy. Most patients are managed with heparin in the acute stage overlapped by warfarin. The case presented here describes a 40-year old man undergoing three episodes of DVT. Investigations revealed protein C and protein S deficiency. Protein C, protein S and antithrombin deficiency either singly or in combination, are relatively common causes of hereditary thrombophilia. The case presented here serves as a reminder of the need to look into the underlying cause of venous thromboembolism.


Deep vein thrombosis; Thrombophilia

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