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Angew Chem Int Ed Engl. 2012 Jul 16;51(29):7198-202. doi: 10.1002/anie.201201176. Epub 2012 Jun 14.

G-rich sequence-specific recognition and scission of human genome by PNA/DNA hybrid G-quadruplex formation.

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  • 1Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan.

Abstract

Hole in one: A single peptide nucleic acid (PNA) effectively targets the G-rich region in double-stranded DNA through formation of a PNA/DNA hybrid G-quadruplex. Only one target site in the whole human genome was selectively cleaved by the hybrid G-quadruplex. Such site-selective scission of DNA is central to gene manipulation for molecular biology, biotechnology, and therapy.

Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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