Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Cancer Biomark. 2011;10(5):213-7. doi: 10.3233/CBM-2012-0249.

VEGF polymorphisms may be associated with susceptibility to colorectal cancer: a case-control study.

Author information

  • 1Molecular Oncology Laboratory, Medical School, University of Patras, Rion, Patras, Greece.


The vascular endothelial growth factor (VEGF) has a pivotal role in angiogenesis. VEGF levels appear to be influenced by single nucleotide polymorphisms (SNPs) of the VEGF gene. The aim of this study was to assess the importance of four VEGF SNPs in modulating susceptibility to colorectal cancer. We have genotyped 223 patients with colorectal cancer and 264 healthy individuals for the -2578C>A, -1498C>T, -634G>C and +936C>T VEGF SNPs using Taqman probes in polymerase chain reactions. The -2578 A, -1498 C and -634 G alleles were more frequently detected in CRC patients compared to healthy controls. Moreover, the haplotype -2578C/-1498T was less frequent in CRC patients while the -2578A/-1498C haplotype was significantly more frequent in patients compared to healthy controls. VEGF -2578C>A and -1498C>T SNPs and -2578/-1498 haplotypes appear to be associated with susceptibility to CRC.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Icon for IOS Press
    Loading ...
    Write to the Help Desk