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BMJ Case Rep. 2011 May 3;2011. pii: bcr0720103178. doi: 10.1136/bcr.07.2010.3178.

Vincristine-induced unilateral ptosis with serendipitous response to modafinil.

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  • 1Department of Radiation Therapy and Oncology, Regional Cancer Center, Shimla, India.


Here we describe a scenario of an atypical manifestation of vincristine-induced neurotoxicity, which responded serendipitously to modafinil. Atypical in that this patient had developed a uniocular ptosis, a rare manifestation of vincristine-induced neurotoxicity. The improvement in neurotoxicity after modafinil was started to alleviate morphine-induced sedation was quite noteworthy.

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