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Appl Opt. 2012 Jun 1;51(16):3461-9. doi: 10.1364/AO.51.003461.

Fast multispectral diffuse optical tomography system for in vivo three-dimensional imaging of seizure dynamics.

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  • 1Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611, USA.


We describe a multispectral continuous-wave diffuse optical tomography (DOT) system that can be used for in vivo three-dimensional (3-D) imaging of seizure dynamics. Fast 3-D data acquisition is realized through a time multiplexing approach based on a parallel lighting configuration--our system can achieve 0.12 ms per source per wavelength and up to a 14 Hz sampling rate for a full set of data for 3-D DOT image reconstruction. The system is validated using both static and dynamic tissue-like phantoms. An initial in vivo experiment using a rat model of seizure is also demonstrated.

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