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FEBS Lett. 1990 Dec 17;277(1-2):59-64.

Sequence analysis of the potent mitogenic toxin of Pasteurella multocida.

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  • 1AFRC Institute for Animal Health, Compton, Newbury, Berkshire, UK.


Pasteurella multocida toxin is a potent mitogen for cultured Swiss 3T3 cells where it causes an accumulation of inositol phosphates and activation of protein kinase C. The gene sequence described here coded for a 146 kDa protein. The ORF was preceded by a ribosome binding site and followed by a stem loop. There was no evidence for a signal sequence. The gene had a low G + C base ratio which differs from the rest of the Pasteurella genome. There was no significant homology with other known proteins, although a motif found in certain bacterial toxins which are ADP-ribosyl transferases is present. A recombinant expressing only part of the PMT gene was not mitogenic.

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