Acoustic droplet vaporization and propulsion of perfluorocarbon-loaded microbullets for targeted tissue penetration and deformation

Daniel Kagan; Michael J Benchimol; Jonathan C Claussen; Erdembileg Chuluun-Erdene; Sadik Esener; Joseph Wang

doi:10.1002/anie.201201902

Acoustic droplet vaporization and propulsion of perfluorocarbon-loaded microbullets for targeted tissue penetration and deformation

Angew Chem Int Ed Engl. 2012 Jul 23;51(30):7519-22. doi: 10.1002/anie.201201902. Epub 2012 Jun 12.

Authors

Daniel Kagan¹, Michael J Benchimol, Jonathan C Claussen, Erdembileg Chuluun-Erdene, Sadik Esener, Joseph Wang

Affiliation

¹ Department of Nanoengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

Abstract

Acoustic droplet vaporization of perfluorocarbon-loaded microbullets triggered by an ultrasound pulse provides the necessary force to penetrate, cleave, and deform cellular tissue for potential targeted drug delivery and precision nanosurgery.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Acoustics
Animals
Drug Carriers / chemistry*
Drug Delivery Systems / instrumentation*
Emulsions / chemistry*
Fluorocarbons / chemistry*
Kidney / metabolism
Sheep
Solubility
Static Electricity
Ultrasonics
Volatilization

Substances

Drug Carriers
Emulsions
Fluorocarbons

Abstract

Publication types

MeSH terms

Substances

Grants and funding