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J Acquir Immune Defic Syndr. 2012 Oct 1;61(2):258-62.

Prevalence of transmitted antiretroviral drug resistance differs between acutely and chronically HIV-infected patients.

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  • 1Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA.


The associations of acute HIV infection (AHI) and other predictors with transmitted drug resistance (TDR) prevalence were assessed in a cohort of HIV-infected, antiretroviral-naïve patients. AHI was defined as being seronegative with detectable HIV RNA. Binomial regression was used to estimate prevalence ratios and 95% confidence intervals for associations with TDR. Among 43 AHI patients, TDR prevalence was 20.9%, whereas prevalence was 8.6% among 677 chronically infected patients. AHI was associated with 1.9 times the prevalence of TDR (95% confidence intervals: 1.0 to 3.6) in multivariable analysis. AHI patients may represent a vanguard group that portends increasing TDR in the future.

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