Possible association of rare autosomal folate sensitive fragile sites and idiopathic mental retardation: a blind controlled population study

Clin Genet. 1990 Oct;38(4):241-56. doi: 10.1111/j.1399-0004.1990.tb03577.x.

Abstract

The expression of folate sensitive fragile sites (FS) was assessed in cord blood lymphocyte cultures obtained from 790 newborns (NB) and in peripheral blood lymphocyte cultures from 326 institutionalized mentally retarded residents (MR). The mean rate of expression of common FS and the occurrence of rare FS was significantly higher in the MR population. Age, sex and history of chronic medication use did not appear to influence common FS expression in the MR population, 3/790 (0.38%) NB and 5/326 (1.53%) MR exhibited rare autosomal folate sensitive FS, a 4-fold difference in incidence (P = 0.009, Poisson test). Four of the five MR who expressed rare FS were considered to have idiopathic MR (4/179 or 2.2%). The occurrence of rare FS in 1/147 (0.68%) MR with known etiology is not significantly different from the frequency of occurrence in the NB population (P = 0.428, Poisson test). In this population, rare FS appear to be overrepresented in the idiopathic etiology MR group.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abnormalities, Multiple / genetics
  • Adult
  • Chromosome Aberrations / genetics*
  • Chromosome Disorders
  • Chromosome Fragile Sites
  • Chromosome Fragility*
  • Female
  • Folic Acid Deficiency / genetics
  • Folic Acid*
  • Gene Expression Regulation / physiology
  • Gene Frequency / genetics*
  • Genetic Carrier Screening
  • Genetic Counseling
  • Genetic Testing
  • Humans
  • Infant
  • Infant, Newborn
  • Intellectual Disability / genetics*
  • Male
  • Phenotype

Substances

  • Folic Acid