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Nanoscale. 2012 Aug 7;4(15):4426-9. doi: 10.1039/c2nr30768e. Epub 2012 Jun 11.

Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method.

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  • 1ETH Zurich, Food & Soft Materials Science, Institute of Food, Nutrition & Health, Schmelzbergstrasse 9, LFO E23, 8092 Zurich, Switzerland.


We report the investigation of the mechanical properties of different types of amyloid fibrils by the peak force quantitative nanomechanical (PF-QNM) technique. We demonstrate that this technique correctly measures the Young's modulus independent of the polymorphic state and the cross-sectional structural details of the fibrils, and we show that values for amyloid fibrils assembled from heptapeptides, α-synuclein, Aβ(1-42), insulin, β-lactoglobulin, lysozyme, ovalbumin, Tau protein and bovine serum albumin all fall in the range of 2-4 GPa.

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