Abstract
A strain of Fusarium solani (Mart.) Sacc. (IMI-216517), isolated from a patient of mycotic keratitis, produced experimental keratomycosis in albino rabbit cornea and survived in internal tissues of albino mice for varying periods. Alantolactone, isolated from the plant - Inula racemosa Hook. f. exhibited marked in vitro fungistatic activity against this strain of F. solani at 100-200 microgram/ml concentrations. The strain was less sensitive to amphotericin B and showed more acid than alkaline proteinase and phosphatase activities.
MeSH terms
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Adult
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Amphotericin B / pharmacology
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Animals
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Antifungal Agents / pharmacology
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Fusarium / drug effects
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Fusarium / enzymology
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Fusarium / isolation & purification*
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Humans
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Keratitis / drug therapy
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Keratitis / microbiology*
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Lactones / pharmacology
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Male
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Mice
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Mycoses / drug therapy
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Mycoses / microbiology*
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Organotin Compounds / pharmacology
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Peptide Hydrolases / metabolism
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Phosphoric Monoester Hydrolases / metabolism
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Rabbits
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Sesquiterpenes / pharmacology
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Thiocarbamates / pharmacology
Substances
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Antifungal Agents
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Lactones
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Organotin Compounds
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Sesquiterpenes
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Thiocarbamates
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Amphotericin B
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Phosphoric Monoester Hydrolases
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Peptide Hydrolases