Studies on a strain of Fusarium solani (Mart.) Sacc. Isolated from a case of mycotic keratitis

Mycopathologia. 1979 Aug 31;68(1):31-8. doi: 10.1007/BF00490388.

Abstract

A strain of Fusarium solani (Mart.) Sacc. (IMI-216517), isolated from a patient of mycotic keratitis, produced experimental keratomycosis in albino rabbit cornea and survived in internal tissues of albino mice for varying periods. Alantolactone, isolated from the plant - Inula racemosa Hook. f. exhibited marked in vitro fungistatic activity against this strain of F. solani at 100-200 microgram/ml concentrations. The strain was less sensitive to amphotericin B and showed more acid than alkaline proteinase and phosphatase activities.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Amphotericin B / pharmacology
  • Animals
  • Antifungal Agents / pharmacology
  • Fusarium / drug effects
  • Fusarium / enzymology
  • Fusarium / isolation & purification*
  • Humans
  • Keratitis / drug therapy
  • Keratitis / microbiology*
  • Lactones / pharmacology
  • Male
  • Mice
  • Mycoses / drug therapy
  • Mycoses / microbiology*
  • Organotin Compounds / pharmacology
  • Peptide Hydrolases / metabolism
  • Phosphoric Monoester Hydrolases / metabolism
  • Rabbits
  • Sesquiterpenes / pharmacology
  • Thiocarbamates / pharmacology

Substances

  • Antifungal Agents
  • Lactones
  • Organotin Compounds
  • Sesquiterpenes
  • Thiocarbamates
  • Amphotericin B
  • Phosphoric Monoester Hydrolases
  • Peptide Hydrolases