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Mediators Inflamm. 2012;2012:159354. doi: 10.1155/2012/159354. Epub 2012 May 17.

Macrolides in chronic inflammatory skin disorders.

Author information

  • 1Dermatology Department, College of Medicine, Qassim University, PO Box 30109, Buraidah 51477, Saudi Arabia. azolibani@yahoo.com

Abstract

Long-term therapy with the macrolide antibiotic erythromycin was shown to alter the clinical course of diffuse panbronchiolitis in the late 1980s. Since that time, macrolides have been found to have a large number of anti-inflammatory properties in addition to being antimicrobials. These observations provided the rationale for many studies performed to assess the usefulness of macrolides in other inflammatory diseases including skin and hair disorders, such as rosacea, psoriasis, pityriasis rosea, alopecia areata, bullous pemphigoid, and pityriasis lichenoides. This paper summarizes a collection of clinical studies and case reports dealing with the potential benefits of macrolides antibiotics in the treatment of selected dermatoses which have primarily been classified as noninfectious and demonstrating their potential for being disease-modifying agents.

PMID:
22685371
[PubMed - indexed for MEDLINE]
PMCID:
PMC3362991
Free PMC Article
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