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Curr Opin Cell Biol. 2012 Aug;24(4):541-6. doi: 10.1016/j.ceb.2012.05.005. Epub 2012 Jun 8.

Centrosome asymmetry and inheritance during animal development.

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  • 1Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada. pelletier@lunenfeld.ca


The centrosome is a subcellular organelle that is responsible for the majority of microtubule organization. Through this ability, the centrosome is involved in cell division, migration, and polarization. Recent studies have revealed intriguing asymmetries between mother and daughter centrioles as well as between mother and daughter centrosomes, and the involvement of such asymmetries in multiple cellular and developmental processes. This review aims to summarize recent discoveries on such asymmetries in centrioles/centrosomes and the potential implication of their inheritance patterns during cell division and development.

Copyright © 2012 Elsevier Ltd. All rights reserved.

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