Send to

Choose Destination
See comment in PubMed Commons below
Zhongguo Fei Ai Za Zhi. 2012 Jun;15(6):340-7. doi: 10.3779/j.issn.1009-3419.2012.06.04.

[A meta analysis of radiosensitivity on non-small cell lung cancer by metronidazole amino acidum natrium].

[Article in Chinese]

Author information

  • 1Evidence-based Medicine Center of Lanzhou University, Lanzhou 730000, China.



The efficacy and safety of radiosensitivity on non-small cell lung cancer (NSCLC) using metronidazole amino acidum natrium (CMNa) are yet to be proven. This study evaluates the efficacy and safety of radiosensitivity on NSCLC by CMNa to provide references for further clinical practice and research.


Relevant randomized controlled trials (RCTs) were obtained from the Cochrane library, Pubmed, EMbase, CBM, CNKI, VIP, and Wan Fang databases. Dates were searched through other means. RCTs of radiosensitivity on NSCLC by CMNa were included. The data included in the study were evaluated and analyzed using the Cochrane Collaboration's RevMan 5.1 software.


A total of 21 RCTs were included. The results of the meta-analyses showed that the total effective rate of the test group that received CMNa plus radiotherapy was higher than that of the control group that received radiotherapy alone (OR=3.29, 95%CI: 2.47-4.39, P<0.000,01) or radiotherapy plus placebo (OR=3.65, 95%CI: 2.25-5.92, P<0.000,01), respectively. No significant differences were found in the quality of life between one and two-year survival rates (P>0.05). No significant differences were found among radiation pneumonitis, radiation esophagitis, hematological toxicity, and cardiotoxicity (P>0.05).


CMNa plus radiotherapy elicit beneficial effects in the treatment of NSCLC and produce fewer adverse effects. Therefore, this technique can be recommended and applied in clinics.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Editorial Office of Chinese Journal of Lung Cancer
    Loading ...
    Write to the Help Desk