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Mol Cell. 2012 Jun 8;46(5):556-7. doi: 10.1016/j.molcel.2012.05.031.

TGF-β drives DNA demethylation.

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  • 1Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA.


In this issue of Molecular Cell, Thillainadesan et al. (2012) provide evidence that Smad proteins promote locus-specific active DNA demethylation as part of the transforming growth factor β (TGF-β) transcriptional response.

Copyright © 2012 Elsevier Inc. All rights reserved.

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