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Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2012 Jun;29(3):255-9. doi: 10.3760/cma.j.issn.1003-9406.2012.03.002.

[Genome-wide association study with memory measures as a quantitative trait locus for schizophrenia].

[Article in Chinese]

Author information

  • 1Psychiatric Laboratory, National Key Laboratory of Biotherapy & Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.



To assess the association between gene polymorphisms and memory function through a genome-wide association study (GWAS) of schizophrenia and control group. Memory cognition was used as a quantitative trait (QT).


Ninty-eight subjects with chronic schizophrenia and 60 matched controls were genotyped with HumanHap660 Bead Array. The results were correlated with quantitative traits including memory and memory delay.


Five candidate genes, including RASGRF2 (rs401758, P = 8.03×10(-5)), PLCG2 (rs7185362, P= 4.54×10(-5)), LMO1 (rs484161, P=9.80×10(-7), CSMD1 (rs2469383, P= 2.77×10(-6)) and PRKG1 (rs7898516, P=6.94×10(-5)) were associated with memory cognition deficits.


Using memory cognition as a quantitative trait, this Genome- wide association study has identified 5 susceptibility loci. With their association with nervous system development, neuronal growth, axon guidance and plasticity, brain development, above loci may play a role in the development of memory dysfunction in schizophrenia.

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