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J Am Acad Dermatol. 2012 Dec;67(6):1335-41. doi: 10.1016/j.jaad.2012.04.013. Epub 2012 Jun 5.

Malignant fibrous histiocytoma: changing perceptions and management challenges.

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  • 1Department of Dermatology, Stanford School of Medicine, Stanford, California, USA. mhenders@stanford.edu

Abstract

Malignant fibrous histiocytoma (MFH) is a rare neoplasm exhibiting a propensity for aggressive clinical behavior. This review seeks to provide the practicing dermatologist with a contemporary understanding of MFH in order to guide management decisions. An extensive review of the literature was conducted using PubMed and OVID databases, searching for articles regarding MFH and undifferentiated pleomorphic sarcoma. The modern conception of MFH has changed extensively from clinical and pathologic standpoints. Limitations of the study included the reliability of past studies given the changing nature of MFH as a diagnostic entity. MFH represents an aggressive neoplasm with unique molecular, immunohistochemical, and behavioral characteristics. Practicing clinicians would benefit from a contemporary understanding of these tumors, particularly as a discussion of advances in the conception of MFH is largely absent in the dermatologic literature.

Copyright © 2012 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

PMID:
22677489
[PubMed - indexed for MEDLINE]
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