Format

Send to:

Choose Destination
See comment in PubMed Commons below
PLoS One. 2012;7(5):e38374. doi: 10.1371/journal.pone.0038374. Epub 2012 May 31.

Healthy lifestyle and leukocyte telomere length in U.S. women.

Author information

  • 1Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America. qisun@hsph.harvard.edu

Abstract

CONTEXT:

Whether a healthy lifestyle may be associated with longer telomere length is largely unknown.

OBJECTIVES:

To examine healthy lifestyle practices, which are primary prevention measures against major age-related chronic diseases, in relation to leukocyte telomere length.

DESIGN AND SETTING:

Cross-sectional analysis in the Nurses' Health Study (NHS).

PARTICIPANTS:

The population consisted of 5,862 women who participated in multiple prospective case-control studies within the NHS cohort. Z scores of leukocyte telomere length were derived within each case-control study. Based on prior work, we defined low-risk or healthy categories for five major modifiable factors assessed in 1988 or 1990: non-current smoking, maintaining a healthy body weight (body mass index in 18.5-24.9 kg/m(2)), engaging in regular moderate or vigorous physical activities (≥150 minutes/week), drinking alcohol in moderation (1 drink/week to <2 drinks/day), and eating a healthy diet (Alternate Healthy Eating Index score in top 50%). We calculated difference (%) of the z scores contrasting low-risk groups with reference groups to evaluate the association of interest.

RESULTS:

Although none of the individual low-risk factors was significantly associated with larger leukocyte telomere length z scores, we observed a significant, positive relationship between the number of low-risk factors and the z scores. In comparison with women who had zero low-risk factors (1.9% of the total population) and were, therefore, considered the least healthy group, the leukocyte telomere length z scores were 16.4%, 22.1%, 28.7%, 22.6%, and 31.2% (P for trend = 0.015) higher for women who had 1 to 5 low-risk factors, respectively.

CONCLUSIONS:

Adherence to a healthy lifestyle, defined by major modifiable risk factors, was associated with longer telomere length in leukocytes.

PMID:
22675460
[PubMed - indexed for MEDLINE]
PMCID:
PMC3365002
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Public Library of Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk