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Int J Endocrinol. 2012;2012:983814. doi: 10.1155/2012/983814. Epub 2012 May 24.

Ectopic fat and insulin resistance: pathophysiology and effect of diet and lifestyle interventions.

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  • 1Departments of Endocrinology & Metabolism and General Internal Medicine, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

Abstract

The storage of triglyceride (TG) droplets in nonadipose tissues is called ectopic fat storage. Ectopic fat is associated with insulin resistance and type 2 diabetes mellitus (T2DM). Not the triglycerides per se but the accumulation of intermediates of lipid metabolism in organs, such as the liver, skeletal muscle, and heart seem to disrupt metabolic processes and impair organ function. We describe the mechanisms of ectopic fat depositions in the liver, skeletal muscle, and in and around the heart and the consequences for each organs function. In addition, we systematically reviewed the literature for the effects of diet-induced weight loss and exercise on ectopic fat depositions.

PMID:
22675355
[PubMed]
PMCID:
PMC3366269
Free PMC Article

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