Format

Send to

Choose Destination
See comment in PubMed Commons below
Eur J Neurol. 2013 Jan;20(1):35-49. doi: 10.1111/j.1468-1331.2012.03757.x. Epub 2012 Jun 4.

Prevention of post-stroke cognitive decline: a review focusing on lifestyle interventions.

Author information

  • 1Department for Clinical Neurosciences and Preventive Medicine, Danube University Krems, Krems, Austria.

Abstract

BACKGROUND AND PURPOSE:

Despite a high prevalence of post-stroke cognitive impairment, therapeutic possibilities are still limited. Stroke and dementia share the same cluster of modifiable risk factors. Thus, lifestyle interventions and strict adherence to medication may not only decrease the risk of recurrent stroke but also the risk of post-stroke cognitive decline.

METHODS:

We performed a systematic literature search for randomized clinical trials (RCTs) targeting modifiable risk factors for the prevention of cognitive decline following stroke.

RESULTS:

We identified 25 non-pharmacological interventions and eight multiple risk factor interventions in stroke patients using cognition as outcome measure. None of the published trials investigated interventions aimed at the prevention of post-stroke cognitive decline. However, a number of ongoing trials aim at risk factor reduction and include measures on cognition.

CONCLUSION:

Evidence for risk factor modification for the prevention of cognitive decline after stroke is scarce and comes mainly from observational studies. There is a need for more RCTs targeting the prevention of post-stroke dementia using lifestyle interventions and a multiple risk factor approach.

© 2012 The Author(s) European Journal of Neurology © 2012 EFNS.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk