Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Reprod Toxicol. 2012 Sep;34(2):261-74. doi: 10.1016/j.reprotox.2012.05.090. Epub 2012 May 29.

Adverse effects on sexual development in rat offspring after low dose exposure to a mixture of endocrine disrupting pesticides.

Author information

  • 1National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK-2860 Søborg, Denmark. ulha@food.dtu.dk

Abstract

The present study investigated whether a mixture of low doses of five environmentally relevant endocrine disrupting pesticides, epoxiconazole, mancozeb, prochloraz, tebuconazole and procymidone, would cause adverse developmental toxicity effects in rats. In rat dams, a significant increase in gestation length was seen, while in male offspring increased nipple retention and increased incidence and severity of genital malformations were observed. Severe mixture effects on gestation length, nipple retention and genital malformations were seen at dose levels where the individual pesticides caused no or smaller effects when given alone. Generally, the mixture effect predictions based on dose-additivity were in good agreement with the observed effects. The results indicate that there is a need for modification of risk assessment procedures for pesticides, in order to take account of the mixture effects and cumulative intake, because of the potentially serious impact of mixed exposure on development and reproduction in humans.

Copyright © 2012 Elsevier Inc. All rights reserved.

PMID:
22659286
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk