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Alzheimers Dement. 2013 Feb;9(1 Suppl):S45-55. doi: 10.1016/j.jalz.2011.11.002. Epub 2012 Jun 1.

Rationale for use of the Clinical Dementia Rating Sum of Boxes as a primary outcome measure for Alzheimer's disease clinical trials.

Author information

  • 1Cytokinetics, Inc., South San Francisco, CA, USA. jcedarbaum@cytokinetics.com

Abstract

BACKGROUND:

We used the database of the Alzheimer's Disease Neuroimaging Initiative (ADNI) to explore the psychometric properties of the Clinical Dementia Rating Sum of Boxes (CDR-SB) to consider its utility as an outcome measure for clinical trials in early and mild, as well as later, stages of Alzheimer's disease (AD).

METHODS:

We assessed internal consistency, structural validity, convergent validity, and 2-year internal and external responsiveness of the CDR-SB using data from 382 subjects with early or mild AD at entry into the ADNI study.

RESULTS:

The CDR-SB assesses both cognitive and functional domains of AD disability. Mean scores declined nearly linearly; CDR-SB cognitive and functional subsums contributed equally to total scores at both very mild (early) and mild stages of the disease.

CONCLUSIONS:

The CDR-SB has psychometric properties that make it attractive as a primary outcome measure that comprehensively assesses both cognitive and functional disability in AD patients. It may prove particularly useful for studies in early, predementia stages of AD.

Copyright © 2013 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

PMID:
22658286
[PubMed - indexed for MEDLINE]
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