Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Prog Mol Biol Transl Sci. 2012;108:323-46. doi: 10.1016/B978-0-12-398397-8.00013-7.

Nutrigenetics and nutrigenomics of caloric restriction.

Author information

  • 1Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain.

Abstract

Obesity is a complex disease resulting from a chronic and long-term positive energy balance in which both genetic and environmental factors are involved. Weight-reduction methods are mainly focused on dietary changes and increased physical activity. However, responses to nutritional intervention programs show a wide range of interindividual variation, which is importantly influenced by genetic determinants. In this sense, subjects carrying several obesity-related single-nucleotide polymorphisms (SNPs) show differences in the response to calorie-restriction programs. Furthermore, there is evidence indicating that dietary components not only fuel the body but also participate in the modulation of gene expression. Thus, the expression pattern and nutritional regulation of several obesity-related genes have been studied, as well as those that are differentially expressed by caloric restriction. The responses to caloric restriction linked to the presence of SNPs in obesity-related genes are reviewed in this chapter. Also, the influence of energy restriction on gene expression pattern in different tissues is addressed.

Copyright © 2012 Elsevier Inc. All rights reserved.

PMID:
22656383
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk