Format

Send to:

Choose Destination
See comment in PubMed Commons below
Acta Naturae. 2010 Oct;2(4):44-51.

The Role of p66shc in Oxidative Stress and Apoptosis.

Author information

  • 1Belozersky Institute of Physico-Chemical Biology, Moscow State University.

Abstract

p66shcis a gene that regulates the level of reactive oxygen species (ROS), apoptosis induction, and lifespan in mammals. Miceknocked out forp66shchave a lifespan~30% longeranddemonstrate an enhanced resistance to oxidative stress and age-related pathologies such as hypercholesterolemia, ischemia, and hyperglycemia. In this respect, p66shc is a promising pharmacological target for the treatment of age-related diseases. In this review, an attempt has been made to survey and put to a critical analysis data concerning the involvement of p66shс in the different signaling pathways that regulate oxidative stress and apoptosis.

KEYWORDS:

apoptosis; mitochondria; p66shc; reactive oxygen species

PMID:
22649663
[PubMed]
PMCID:
PMC3347587
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk