Access to C(sp3)-C(sp2) and C(sp2)-C(sp2) bond formation via sequential intermolecular carbopalladation of multiple carbon-carbon bonds

Yanmei Wen; Liangbin Huang; Huanfeng Jiang

doi:10.1021/jo300662x

Access to C(sp3)-C(sp2) and C(sp2)-C(sp2) bond formation via sequential intermolecular carbopalladation of multiple carbon-carbon bonds

J Org Chem. 2012 Jun 15;77(12):5418-22. doi: 10.1021/jo300662x. Epub 2012 Jun 5.

Authors

Yanmei Wen¹, Liangbin Huang, Huanfeng Jiang

Affiliation

¹ School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.

PMID: 22647071
DOI: 10.1021/jo300662x

Abstract

A synthetic strategy of 4-benzyl-substituted 1,3-butadiene derivatives through Pd-catalyzed three-component coupling reaction of benzyl chlorides, alkynes, and monosubstituted alkenes is described. This tandem coupling reaction forms a C(sp(3))-C(sp(2)) bond and a C(sp(2))-C(sp(2)) bond sequentially in a single-step operation.